Research Roundup: The first chlamydia vaccine passed a major test, a new drug approved for drug-resistant tuberculosis, and two new Ebola treatments prove highly effective in the DRC

Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign-up now to receive our weekly R&D News Roundup email. Last Friday, the World Health Organization (WHO) launched the findings of its malaria eradication report, a three-year long analysis of the global fight against the mosquito-borne disease, calling for “transformative tools and knowledge” to achieve eradication. A summary of the report noted that current tools are not sufficient to wipe out the disease and urged scientists and global health funders to invest in research and development (R&D) of new vector control technologies, vaccines, and medicines to prevent and treat the disease. Currently, less than one percent of investment in health R&D goes to developing tools to tackle malaria. The report calls attention to the funds, tools, and political will needed to control the disease considering WHO data which shows that progress against malaria is stalling after a decade of significant decline in malaria cases and deaths. A phase 3 study from GSK’s ViiV Healthcare showed an injection of its drug cabotegravir and Johnson & Johnson’s Edurant (rilpivirine) could work just as well when given every two months as it does as a monthly therapy. An application of this two-drug injectable regimen as a once-monthly injection has already been put under US Food and Drug Administration priority review with a decision expected by December 29. In two earlier phase 3 trials, the long-acting injectable therapy was found to be as effective as both an oral three-drug regimen of two nucleoside reverse transcriptase inhibitors plus a third agent and ViiV’s own triple drug therapy, Triumeq, in reducing viral load. These results demonstrate progress in efforts to reduce the number of medicines a person living with HIV must take as well as the frequency of treatments. British technology and energy company, Sure Chill, has developed a refrigerator to protect medical supplies, such as vaccines, from power outages. Vaccines are often temperature sensitive to both high and low temperatures, which presents a major challenge for health workers in low-resource settings with limited or unreliable electricity supplies. The refrigerator works by harnessing a natural phenomenon. The refrigerator has a cold compartment that is surrounded by water that cools when connected to power, forming a layer of ice above the chamber. When the electricity is shut off, the warm water rises as the ice melts, keeping the water at a consistent temperature for up to four weeks without power. The refrigerator has kept more than 20 million vaccinations cold and has been approved for use by the WHO.

Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign-up now to receive our weekly R&D News Roundup email. Researchers at Purdue University have created a device that can rapidly detect the bacterium which causes cholera in water. Unlike traditional tests, which require a well-equipped laboratory and three to five days to process results, this device acts as a portable “cholera detection lab” built around a smartphone. A water sample is placed in a single-use, disposable test kit which uses chemicals that make copies of the toxin gene in cholera bacteria in a process called amplification. If the water becomes more viscous, it signals that harmful bacteria has been identified and the imaging system on the smartphone will capture the results, which can be sent to researchers or charities who can address the water quality issue. The device is currently in early field testing. The nonprofit Sabin Vaccine Institute (Sabin) has acquired the rights from GSK to develop three experimental, single-dose vaccines for Marburg virus, Ebola Sudan, and Ebola Zaire—the strain of the Ebola virus responsible for the yearlong outbreak in the Democratic Republic of the Congo (DRC). Sabin will develop these vaccines in collaboration with the National Institutes of Health Vaccine Research Center, whose scientists originally designed the vaccines which all use the same approach to induce immunity. Though the vaccines have not been tested in phase 3 trials, which would show their efficacy in preventing infection, a phase 2 trial conducted at the end of the West African Ebola outbreak showed that the Ebola Zaire vaccine produced an antibody response in most recipients that lasted up to a year. The largest-ever trial of a preventive Ebola vaccine in Uganda began last week, amid fears of the virus spreading from neighboring DRC. The two-year trial, which will test a two-dose Ebola candidate vaccine developed by Janssen Pharmaceuticals of Johnson & Johnson, will involve 800 participants picked from core health workers and non-core personnel in the Mbarara district, located in the southwest of the country, and will assess the vaccine’s safety and efficacy in inducing an immune response to prevent the disease. The trial will be conducted by both Ugandan and international researchers and is sponsored by the London School of Hygiene and Tropical Medicine. Ebola has killed more than 1,800 people in the DRC during this latest outbreak, which began over a year ago.